Hepatitis C Blog

Greg Jefferys Hepatitis C blog deals with all the issues associated with hepatitis C

Taking Sofosbuvir and Daclatasvir

Tips for taking Sofosbuvir + Daclatasvir

Food, Diet Advice when taking Sofosbuvir + Daclatasvir

Here are a few tips for people treating their Hepatitis C with Sofosbuvir 400 mg + Daclatasvir 60 mg.

Sofosbuvir and Daclatasvir are both water soluble and are absorbed into the bloodstream through the stomach.

If you have a Sofosbuvir pill and a separate Daclatasvir pill these pills should be taken together at the same time each day.

The pills should be taken with a small amount of food and not too much water or other beverages. The reason for this is taking the pills with a small amount of food will hold the medicines in the stomach for the maximum time, ensuring absorption of the active ingredients.

Because Sofosbuvir can cause insomnia in some people it may be wise to that the pills in the morning with breakfast.

Coffee and tea should only be taken in moderation while using Sofosbuvir and Daclatasvir. The reason for this is that the enzymes, called CYP enzymes, used by the body to remove caffeine from the blood are from the same family of enzymes that the body uses to remove Sofosbuvir and Daclatasvir from the blood. High levels of caffeine may create an “under-dose” situation.

Having said that one or two cups of coffee or tea is no problem at all.

Energy Drinks and Sofosbuvir + Daclatasvir

Energy Drinks such as Red Bull and other brands contain high levels of caffeine and another stimulant called Taurine. Taurine will also stimulate production of CYP enzymes and so Energy drinks should be avoided.

Herbal Supplements During Hepatitis C Treatment

High levels of these CYP enzymes can also be caused by some drugs and herbal supplements, particularly St John’s Wort. It is wise to avoid any herbal supplements while doing Hepatitis C treatment with Sofosbuvir + Daclatasvir.

Food and Hepatitis C Treatment

There are no common foods that cause any problematic interactions with Sofosbuvir and Daclatasvir.

There is something of a myth going around that food like grapefruit, papaya and so on should be avoided.

This is not entirely correct.

The reason behind this myth is that certain fruits will slightly suppress production of the CYP enzymes (the enzymes that break down Sofosbuvir and Daclatasvir). What this means is that by eating these foods while doing Hep C treatment the Sofosbuvir and Daclatasvir will remain active in the blood a little longer, which is probably not a bad thing.

To put this simply and in perspective the half-life of Sofosbuvir in your blood is about 20 minutes. That means that if your body absorbs 400 mg of Sofosbuvir 20 minutes later there will be only 200 mg of Sofosbuvir. After 40 minutes there will be about 100 mg and after an hour about 50 mg.

If you were to eat several grapefruit or a couple of papaya the effect might be that at the end of an hour you might have 60 or 70 mg left instead of 50 mg… its not a problem. You would need to eat about several grapefruit to make any real significant difference.

Taking other medication while doing Hepatitis C Treatment.

If you are on other medication you should check with your doctor to make sure there are no clashes between the Hep C medication and your other medicines. If you want to check for yourself there is a very good website which has an interactive chart that lists all Hep C medicines and other medications and you can check you medicine on this. Here is the link:



Whilst taking Sofosbuvir + Daclatasvir (or any DAA)  to treat Hepatitis C a sensible diet containing fresh fruit and vegetables is the main requirement. Avoid supplements of any kind during treatment.

Once treatment is complete then, if you use particular herbal or vitamin supplements, then you can resume.

To give your liver the best chance to heal the healthy diet combined with regular exercise is the best path to follow.

Given a chance your liver will be able to completely heal from the damage done by Hep C.





Diet After Hep C Treatment

Greg Jefferys

Greg Jefferys


  •    Reply

    Thank you very much for such an informative comments Greg Jeffrey. God Bless & gave A Nice Day.

    •    Reply

      Thank you Greg for the information I will be so happy to get started The end of the week. Thanks too you. Your such a blessing to so many people! I will be so happy to be able to eat again without thowing up or being sick at my stomach

  •    Reply

    Thanks for the info. I should begin treatment when I return from vacation.

  •    Reply

    Hi Greg
    2 years and virus free. My decompensated cirrous is now just cirrous. Thanks to your courageous and outstanding humanitarianism I am still alive and I stand in eternal gratitude!!!!!!!
    It looks like the Tasmanian fires are terrible. Here on the U.S. west coast we know your situation. The smoke has been awful here the last several summers. Winter is warm and dry so far this year. I fear next summer’s fires will be even worse then the last few years.
    Paul Mourse

  •    Reply

    Great content as usual. So much positive energy generated. I soak it all up – lol. Great outcomes are always the best and that is surely the case here. Thanks for spearheading the endeavor to rid the universe of a health, life, and joy snatcher called Hepatitis C . Eternal Gratitude ! I would love to see your part of the world and i can look forward to more adventures in good health. Good health to you & yours Greg Jefferys!

  •    Reply

    Thanks for all the info.Newly diagnosed with hep c.Did not get a lot of info from the dr mostly printed brochures from the drug companies.Waiting to see which would be the most cost effective

    •    Reply

      Hi Erika
      It is almost universally acknowledged that Sofosbuvir + Daclatasvir is the most cost effective, and effective, treatment for Hepatitis C. It does not get much publicity because the patents are owned by rival drug companies… so we have the insane situation where the best and cheapest treatment is widely ignored because two global pharmaceutical giants choose to ignore it in order to maximise their profits on their own brand drugs

  •    Reply

    Short, sweet and maximally efficient for the reader!
    You can read all about HCV via your blog and posts in about two hours.
    All the knowledge needed to be cured put together into few articles… But We know that it took you a while to compile the articles. Thanks for all your help and support Greg!
    Regards from Belgrade / Serbia 🇷🇸

  •    Reply

    Im verry tnxfull for once more friendly tip and hardly waith my cure …ciirosies keeps me stupid and just can be peacfull now …hardly finde words to express faith in sofo-decla efeckt to makes me easy out from nightemare named hepC. Love and respeckt is shure what can said/wrighte.

  •    Reply

    My question is that If you start taking the pills at different times daily, without knowing
    that you re main to take it together, and want to start taking it together at the same time. Is it possible?

    •    Reply
      Greg Jefferys July 2, 2020 at 8:11 am

      If you are taking Sofosbuvir + Daclatasvir the pills should be taken together. If you have been taking them at different times then you should correct this immediately

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