What is the best Hepatitis C Treatment?

Background

In 2014 I was six months into my PhD at the University of Tasmania when I suddenly became very, very sick. To cut a long story short I discovered that I had Hepatitis C.

Back in 2014 the only treatment option I could access was Sovaldi, but it was more than $100,000 for a treatment, which I did not have. So in May 2015 I went to India and purchased generic Sovaldi and I treated myself with a combination of Sovaldi (Sofosbuvir 400 mg) + Ribavirin. Three months later I was cured.

Later that year generic Harvoni became available and then generic Daclatasvir and then generic Epclusa. Then Mavyret arrived on the scene.

With the availability of so many new treatments, and with the drug companies spending vast fortunes on advertising it became hard to decide which Hepatitis C treatment was actually the best.

Mavyret Vs Sofosbuvir + Daclatasvir for Hep C Genotype 3

This graph compares Mavyret (G/P) with Sofosbuvir + Daclatasvir for treating Hep C genotype 3. As you see Sof + Dac is superior to Mavyret

These two graphs are from separate studies. One shows cure rates for Sofosbuvir + Daclatasvir across all genotypes of Hepatitis C and the other shows cure rates for Mavyret across all genotypes of Hepatitis C. The difference in cure rates is so small as to be relatively insignificant. In other words Mavyret or Sofosbuvir + Daclatasvir could be said to be equally effective. The BIG difference lies in the price. A treatment with Mavyret will cost at least US,000 whereas a treatment using Sofosbuvir + Daclatasvir will cost not more than US0.

Harvoni for Hep C Genotype 1. 12 weeks vs 24 weeks

This Graph shows that 12 weeks treatment with Harvoni gives a 95% cure rate for people without cirrhosis. It also demonstrates the fact that “The Longer the Treatment the Higher the Cure Rate”

Epclusa for all genotypes of Hep C. 12 weeks vs 24 weeks. Treatment with and without Ribavirin

This graph shows that 12 weeks treatment with Epclusa (Sof+ vel) only gives an 85% cure rate for G3 and only if Ribavirin is added

Harvoni vs Sofosbuvir + Daclatasvir Hep C Genotype 1

This graph shows that 12 weeks of Sofosbuvir + Daclatasvir gives a cure rate of better than 97% for Genotype 1. Better than Maviret, Epclusa and Harvoni

Sofosbuvir + Daclatasvir for Hep C Genotype 2 (Co-infection)

This graph shows that for people with genotype 2 a 12 week treatment of Sofosbuvir + Daclatasvir gives a 100% cure rate

Sofosbuvir + Daclatasvir Hep C Genotype 3: with and without cirrhosis

This Graph shows that for people without cirrhosis and who have not failed a previous treatment Sof + Dac gives a 95% cure rate equal to, or better than, Epclusa or Mavyret

Sofosbuvir + Daclatasvir for Hep C Genotype 1.

This graph shows that Sofosbuvir + Daclatasvir gives 100% cure rate for G1b and a 97% cure rate for G1a. Both results are better than Harvoni, Maviret and Epclusa

Sofosbuvir + Daclatasvir vs Epclusa  for Hep C genotype 2 and genotype 3.

This graph shows that Sofosbuvir + Daclatasvir is equal to or better than Epclusa except where the patient has a high level of Fibrosis or Cirrhosis

This graph shows people who have not failed a previous treatment and do not have cirrhosis have a 97% cure rate from Sofosbuvir + Daclatasvir

• Post Categories
• Uncategorized