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What is the best Hepatitis C Treatment?

What is the best Hepatitis C Treatment?

Every day I get emails from people around the world asking for advice about Hepatitis C treatment. They are asking about which medicine they should get and what price they should pay and how long they should do the Hepatitis C treatment for.

Now I am not a doctor and have no formal medical training but I have lived and breathed Hepatitis C seven days a week 365 days a year since 2014 when I first learned that I was infected with Hepatitis C.

Whilst I am not a medical man I do, however, have a Bachelor of Arts degree, a Diploma in Education and a Masters Degree in History and I was 6 months into my PhD when I learned I had Hep C. So I am no dummy and I am quite capable of doing serious formal research.

So in this post I am going to show you which is the best, and most affordable, Hepatitis C treatment based on the results of solid scientific research done by many different internationally recognised research groups.

And I am going to say now that the best value all round Hep C treatment is Sofosbuvir 400 mg + Daclatasvir 60. In almost every situation, for every genotype Sofosbuvir + Daclatasvir is equal to, or better than, Epclusa, Maviret or Harvoni and it is also the least expensive at US0 for a 12 weeks treatment.


In 2014 I was six months into my PhD at the University of Tasmania when I suddenly became very, very sick. To cut a long story short I discovered that I had Hepatitis C.

Back in 2014 the only treatment option I could access was Sovaldi, but it was more than $100,000 for a treatment, which I did not have. So in May 2015 I went to India and purchased generic Sovaldi and I treated myself with a combination of Sovaldi (Sofosbuvir 400 mg) + Ribavirin. Three months later I was cured.

Later that year generic Harvoni became available and then generic Daclatasvir and then generic Epclusa. Then Mavyret arrived on the scene.

With the availability of so many new treatments, and with the drug companies spending vast fortunes on advertising it became hard to decide which Hepatitis C treatment was actually the best.

Below are graphs from various studies that show how the different drug combinations perform against the different Hepatitis C genotypes. Look through them yourself and make up your own mind. I have made a little comment at the bottom of each graph.



Mavyret Vs Sofosbuvir + Daclatasvir for Hep C Genotype 3

Maviret vs Sofosbuvir + Daclatasvir

This graph compares Mavyret (G/P) with Sofosbuvir + Daclatasvir for treating Hep C genotype 3. As you see Sof + Dac is superior to Mavyret

Mavyret compared to Sofosbuvir + Daclatasvir

These two graphs are from separate studies. One shows cure rates for Sofosbuvir + Daclatasvir across all genotypes of Hepatitis C and the other shows cure rates for Mavyret across all genotypes of Hepatitis C. The difference in cure rates is so small as to be relatively insignificant. In other words Mavyret or Sofosbuvir + Daclatasvir could be said to be equally effective. The BIG difference lies in the price. A treatment with Mavyret will cost at least US,000 whereas a treatment using Sofosbuvir + Daclatasvir will cost not more than US0.

Harvoni for Hep C Genotype 1. 12 weeks vs 24 weeks


This Graph shows that 12 weeks treatment with Harvoni gives a 95% cure rate for people without cirrhosis. It also demonstrates the fact that “The Longer the Treatment the Higher the Cure Rate”


Epclusa for all genotypes of Hep C. 12 weeks vs 24 weeks. Treatment with and without Ribavirin


This graph shows that 12 weeks treatment with Epclusa (Sof+ vel) only gives an 85% cure rate for G3 and only if Ribavirin is added


Harvoni vs Sofosbuvir + Daclatasvir Hep C Genotype 1

Sof + Dac

This graph shows that 12 weeks of Sofosbuvir + Daclatasvir gives a cure rate of better than 97% for Genotype 1. Better than Maviret, Epclusa and Harvoni


Sofosbuvir + Daclatasvir for Hep C Genotype 2 (Co-infection)

Genotype 2

This graph shows that for people with genotype 2 a 12 week treatment of Sofosbuvir + Daclatasvir gives a 100% cure rate


Sofosbuvir + Daclatasvir Hep C Genotype 3: with and without cirrhosis

Genotype 3

This Graph shows that for people without cirrhosis and who have not failed a previous treatment Sof + Dac gives a 95% cure rate equal to, or better than, Epclusa or Mavyret


Sofosbuvir + Daclatasvir for Hep C Genotype 1.


This graph shows that Sofosbuvir + Daclatasvir gives 100% cure rate for G1b and a 97% cure rate for G1a. Both results are better than Harvoni, Maviret and Epclusa


Sofosbuvir + Daclatasvir vs Epclusa  for Hep C genotype 2 and genotype 3.

This graph shows that Sofosbuvir + Daclatasvir is equal to or better than Epclusa except where the patient has a high level of Fibrosis or Cirrhosis



Hep C treatment

This graph shows people who have not failed a previous treatment and do not have cirrhosis have a 97% cure rate from Sofosbuvir + Daclatasvir



Greg Jefferys

Greg Jefferys


  •    Reply

    Good morning Sr Gref if my sister need 16 weeks of treatment what is the price? only l need this for buy

  •    Reply

    This is the first article I’ve read of yours…so I apologize if the answer is obvious somewhere else. My husband has lived with Hep C for 23 years and is now 43. We’ve always kept it at bay using acupuncture, but we are ready to just get it out of his system. Where do you actually suggest going to get these drugs to eradicate it from his body? Thank you for your time!

    •    Reply

      Hi Nikki
      I have replied to you by email. I will certainly do the best I can to help your husband clear the Hep C

  •    Reply


    I just read your articles after reserching the right treatments for my aunt. She lives in Serbia and I am in Delhi. Her doctors are telling her not to go for generic Indian medicines. And my pharmacist here tells me it is just a metter of cost.
    She has type 1 hep c since she was 9. Now she is in her 60’s.
    A decade ago she developed very bad itching with rash that stained her skin. It is not passing and on top of it this summer she developed cirrhosis. The course of treatment prescribed by her doctor is: sofosbuvir/ledipasvir and Ribavirin 2x600mg for 12 weeks. Here in India Ribavirin is available only in 200mg tablets. I worry that taking 6 of them daily will not do her stomach good.
    Any advice perhaps?
    Thank you so much

    •    Reply

      HI Ivana
      Yes I will be happy to give you any help I can. Please simply email me direct and I will pass on contact details of reliable people
      and any advice you need.

  •    Reply

    Hi Greg,

    Maybe I missed it from your article but do you know if there’s a generic version of Mayvret out there yet? Much thanks for all you’re doing.


    •    Reply

      Hi Robert
      At the moment there is no generic version of Mavyret and I have heard no news of any generic Mavyret appearing in the near future.
      However, as mentioned in the article you read, Sof + Dac is equal to, or superior to, Mavyret Best wishes Greg

  •    Reply


    I have lived with HEPC for 20 + years and have not had any real symptoms, but would like to eradicate it before I do. Can you please email me your study and your source for the Sof + Dac treatment you have described. I was going to do the Harvoni and then decided to do the Mavyret, but now I am impressed with your research and would rather give it a try. Great Job man! You should be proud of yourself.

    Best Regards, Mark

    •    Reply
      Greg Jefferys March 8, 2019 at 3:26 am

      Hi Mark
      Thanks for your comment. I had some problems with the email address you entered but I think I have now sent you the information

  •    Reply
    Douglas Charles Larsen April 2, 2019 at 5:01 am

    My name is Douglas Larsen. I contacted you via Facebook today. I’ve had symptom free, type 2 Hepatitis C since 1992. It is my only and hence, number 1 health concern in my life. I’m not sure of the treatment I’d need, but contact me, and I hope you can help me with obtaining the necessary drugs.

  •    Reply

    I have HepC -Genome 3 and was treated previously with combo of sovaldi and
    Ribovirin 2015, cured in Oct . Cirrhosis increased and now have HCC heptoclellular carcinoma
    The surprise is the Hep C is back . Which medication or regiment is recommended for 61 yr old male dealing with Hep C as well as HCC ? Please let me know so I can then share with my doctors .

    •    Reply

      Hi Michael
      I have written to you by email. If you have not received my email please check your SPAM filter or do write to me directly

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