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Guidelines For Taking Harvoni

Harvoni doses

Here are some simple tips for taking Harvoni

Some Tips For Taking Harvoni

(These guidelines for taking Harvoni equally apply to taking generic Harvoni because generic Harvoni and Harvoni are chemically identical)

What is Harvoni

Harvoni is the combination of two drugs Sofosbuvir 400 mg plus Ledipasvir 90 mg. It is the Ledipasvir which makes Harvoni particularly effective against Hepatitis C genotype 1.

One of the BIG issues in the current Hep C treatment world is reducing the possibility of relapse.

About 1 in 35 people treating with Sofosbuvir 400 mg + Ledipasvir 90 mg (Harvoni) will relapse.

Why Hepatitis C treatment relapses happen is not entirely clear however I would like to shed a little light on the process and give some tips for taking Harvoni that might help make a small difference and reduce the chance of you having a relapse.

Ledipasvir is not water-soluble

The first thing to understand when you are taking Harvoni is that Ledipasvir is not a very soluble chemical. That is to say it does not dissolve easily.

Sofosbuvir is very soluble, Ledipasvir is not.

Ledipasvir relies heavily on the stomach acids to dissolve it and make and to make the whole parcel of two drugs that is Harvoni easy for the body to absorb.

No Antacids

This is why you must never take antacids when you are taking Harvoni. Antacids neutralize your stomach acids and then that will reduce how much Ledipasvir is dissolved and absorbed.

On the instructions that come with the bottle of Harvoni it says that Harvoni can be taken with or without food.

Some simple guidelines for taking Harvoni to make sure that you get the maximum benefits from your Hep c treatment

Take Harvoni with food

However, in my opinion, it is better to take your pill with a small amount of food.


Because having a small amount of food in the stomach will stimulate the stomach acids and assist in the absorption process.

Not a large amount of food, not a huge meal, because some of the Ledipasvir is going to get caught up in the mass of food.

Also I would not suggest drinking a large amount of water right after taking your pill or to wash the Harvoni pill down.

For the same reason.

We want that Ledipasvir to hang around in some nice strong stomach acid for a while, not get washed away in a flood of H20.

No Herbal Supplements While Taking Harvoni

Some herbs will cause your liver to make enzymes, called CYP enzymes, used by the body to remove toxins from the blood are from the same family of enzymes that the body uses to remove Sofosbuvir and Ledipasvir from the blood so high CYP levels can lead to “under-dosing.

High levels of these CYP enzymes can also be caused by some drugs and herbal supplements, particularly St John’s Wort. It is wise to avoid any herbal supplements while doing Hepatitis C treatment with Harvoni as

So in summary:

Take your pill at about the same time each day.

Take it with a small amount of food.

Don’t drink too much water immediately after taking your pill.

No antacids and its probably a good idea not to take magnesium supplement during treatment.

No Herbal Supplements

Good luck

Tips For Taking Harvoni

Greg Jefferys

Greg Jefferys


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